The Pathophysiology of Liver Disorders

and Pharmacotherapy Options with Special

Reference to Traditional Herbal Medicines:

A Comprehensive Review

29

Hasandeep Singh, Tanveer Singh, Harpal Singh Buttar,

Sarabjit Kaur, Saroj Arora, Istvan G. Télessy, and Balbir Singh

Abstract

Besides synthetic drugs, a wide variety of medicinal plants have been used for the

prevention and management of various liver disorders. Generally, plant therapies

are well tolerated due to their lesser side effects. The aims and objectives of this

review are to describe the drug therapies used for treating liver disorders as well

as the most commonly used hepatoprotective plant-derived bioactive ingredients

and their formulations employed for treating various liver pathologies. The

extensive literature review was conducted using different databases such as

ScienceDirect, SciFinder Scholar, Wiley Online Library, PubMed, ResearchGate,

Google Scholar and Chemical Abstracts (until March 2021). Our literature

searches showed that a wide array of plant products or plant extracts have been

used in the folklore and traditional remedies for the prevention and management

of liver disorders. The complex chemical structures of many isolated plant

H. Singh · S. Kaur · B. Singh (*)

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India

e-mail: hasanpharma.rsh@gndu.ac.in; sarabjit.pharma@gndu.ac.in; balbir.pharma@gndu.ac.in

T. Singh

Department of Neuroscience and Experimental Therapeutics, Texas A&M University College of

Medicine, Bryan, TX, USA

e-mail: tanveersingh@tamu.edu

H. S. Buttar

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, India

S. Arora

Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa,

Ottawa, ON, Canada

I. G. Télessy

Department of Pharmaceutics, Faculty of Pharmacy, University of Pécs, Pécs, Hungary

e-mail: telessyist@vnet.hu

# The Author(s), under exclusive license to Springer Nature Singapore Pte

Ltd. 2022

R. C. Sobti, N. S. Dhalla (eds.), Biomedical Translational Research,

https://doi.org/10.1007/978-981-16-9232-1_29

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